Breckin Meyer
Jon
Jennifer Love Hewitt
Liz
Stephen Tobolowsky
Happy Chapman
Evan Arnold
Wendell
Mark Christopher Lawrence
Christopher Mello
Daamen J. Krall
Announcer
Bill Murray
Garfield
Jimmy Kimmel
Spanky (voice)
Debra Messing
Arlene (voice)
Nick Cannon
Louis (voice)
Alan Cumming
Persnikitty (voice)
Brad Garrett
Luca (voice)
David Eigenberg
Nermal (voice)
Jerry Hauck
Cop
Richard Kind
Dad Rat (voice)
Vanessa Campbell
Miss Ace Hardware
Alyson Stoner
Kid Rat (voice)
Eve Brent
Mrs. Baker
Bill Hoag
Roy the Lodge Member
Ben Kronen
Older Man
Michael Monks
Deputy Hopkins
Mel Rodriguez
Security Officer
Juliette Goglia
Little Girl
Joseph Edward Taylor
Frank